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Tablet Coamoxiclave (Amoxicillin +clavulanic Acid) Indications and Dos

The document provides dosing information for the antibiotic Coamoxiclav (amoxicillin + clavulanic acid) tablet. It lists 7 indications for use including respiratory infections, dental infections, surgical prophylaxis, and ear infections. For each indication, it provides the dosage depending on factors like age and severity of infection. It can be given by mouth as tablets or by intravenous injection or infusion. It notes the importance of strict compliance to dosage to prevent antibiotic resistance.

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Shumaila Iftikhar Iftikhar Ahmad
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226 views2 pages

Tablet Coamoxiclave (Amoxicillin +clavulanic Acid) Indications and Dos

The document provides dosing information for the antibiotic Coamoxiclav (amoxicillin + clavulanic acid) tablet. It lists 7 indications for use including respiratory infections, dental infections, surgical prophylaxis, and ear infections. For each indication, it provides the dosage depending on factors like age and severity of infection. It can be given by mouth as tablets or by intravenous injection or infusion. It notes the importance of strict compliance to dosage to prevent antibiotic resistance.

Uploaded by

Shumaila Iftikhar Iftikhar Ahmad
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

THQ HOSPITAL PIND DADAN KHAN

DEPARTMENT OF PHARMACEUTICAL SERVICES


DRUG INFORMATION SERVICES
TABLET COAMOXICLAVE (AMOXICILLIN +CLAVULANIC ACID)
AVAILABLE STRENGTH :500+150 mg

INDICATIONS AND DOSE

1. INFECTIONS DUE TO BETA-LACTAMASE-PRODUCING STRAINS (WHERE AMOXICILLIN


ALONE NOT APPROPRIATE), INCLUDING RESPIRATORY TRACT INFECTIONS, BONE AND
JOINT INFECTIONS, GENITO-URINARY AND ABDOMINAL INFECTIONS, CELLULITIS AND
ANIMAL BITES
▶ BY MOUTH USING TABLETS
 Child 12–17 years: 250/125 mg every 8 hours; increased to 500/125 mg every 8 hours, increased
dose used for severe infection
 Adult: 250/125 mg every 8 hours; increased to 500/125 mg every 8 hours, increased dose used
for severe infection
▶ BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
 Child 1–2 months: 30 mg/kg every 12 hours, intravenous infusion recommended in children less
than 3 months
 Child 3 months–17 years: 30 mg/kg every 8 hours (max. per dose 1.2 g every 8 hours)
 Adult: 1.2 g every 8 hours
2. SEVERE DENTAL INFECTION WITH SPREADING CELLULITIS | DENTAL INFECTION NOT
RESPONDING TO FIRST-LINE ANTIBACTERIAL
▶ BY MOUTH USING TABLETS
 Child 12–17 years: 250/125 mg every 8 hours for 5 days
 Adult: 250/125 mg every 8 hours for 5 days
3. SURGICAL PROPHYLAXIS
▶ BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
 Adult: 1.2 g, to be administered up to 30 minutes before the procedure, then 1.2 g every 8
hours for up to 2–3 further doses in high-risk procedures
4. ACUTE EXACERBATION OF BRONCHIECTASIS
▶ BY MOUTH USING TABLETS
 Child 12–17 years: 250/125 mg 3 times a day for 7–14 days, alternatively 500/125 mg 3 times a
day for 7–14 days
 Adult: 500/125 mg 3 times a day for 7–14 days
▶ BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION
 Child 1–2 months: 30 mg/kg every 12 hours, intravenous infusion is recommended in children
less than 3 months
 Child 3 months–17 years: 30 mg/kg every 8 hours (max. per dose 1.2 g every 8 hours)
 Adult: 1.2 g every 8 hours

DRUG INFORMATION SERVICES

REFERENCE:BNF 2019-2020
THQ HOSPITAL PIND DADAN KHAN
DEPARTMENT OF PHARMACEUTICAL SERVICES
TABLET COAMOXICLAVE (AMOXICILLIN +CLAVULANIC ACID)
AVAILABLE STRENGTH :500+150 mg

5. ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE


▶ BY MOUTH USING TABLETS
 Adult: 500/125 mg 3 times a day for 5 days
▶ BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
 ▶ Adult: 1.2 g every 8 hours
6. ACUTE SINUSITIS
▶ BY MOUTH USING TABLETS
 ▶ Child 12–17 years: 250/125 mg 3 times a day for 5 days, alternatively 500/125 mg 3 times a
day for 5 days
 ▶ Adult: 500/125 mg 3 times a day for 5 days
7. ACUTE OTITIS MEDIA
▶ BY MOUTH USING TABLETS
 ▶ Child 12–17 years: 250/125 mg 3 times a day for 5–7 days, alternatively 500/125 mg 3 times
a day for 5–7 days

Note:
a. In order to encounter antibiotic resistance strict compliance to dose is necessary.

b. The 250 mg and 500 mg tablets of amoxicillin and clavulanic acid contain the same
amount of clavulanic acid. Do not substitute two 250 mg tablets for one 500 mg tablet.
The 250 mg regular tablet and the 250 mg chewable tablet contain different amounts of
clavulanic acid. They also should not be substituted.

Hospital Pharmacist Medical Superintendent

REFERENCE:BNF 2019-2020

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