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Fructose Metabolism

This document discusses fructolysis, the breakdown of fructose. It notes that dietary sources of fructose include sucrose and fruits. Fructose provides 15% of daily energy and is the main energy source for sperm. Fructose is broken down in the liver, kidneys, and small intestine by fructokinase converting it to F1P, then cleaved by aldolase B to DHAP and glyceraldehyde. In other tissues, hexokinase can phosphorylate fructose. The document also discusses how glucose can be reduced to sorbitol by aldose reductase and then oxidized to fructose without ATP by sorbitol dehydrogenase in certain tissues.

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Rith Hengmeng (Study Smart)
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31 views5 pages

Fructose Metabolism

This document discusses fructolysis, the breakdown of fructose. It notes that dietary sources of fructose include sucrose and fruits. Fructose provides 15% of daily energy and is the main energy source for sperm. Fructose is broken down in the liver, kidneys, and small intestine by fructokinase converting it to F1P, then cleaved by aldolase B to DHAP and glyceraldehyde. In other tissues, hexokinase can phosphorylate fructose. The document also discusses how glucose can be reduced to sorbitol by aldose reductase and then oxidized to fructose without ATP by sorbitol dehydrogenase in certain tissues.

Uploaded by

Rith Hengmeng (Study Smart)
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

 Contents :

 Fructolysis
 Fructose synthesis

By: Savath Sovannak


 Dietary source of fructose :
 Sucrose
 Fructose as monosaccharide present in : fruit,
honey, vegetable….
 Important of fructose :
 Production of energy : 15% of daily energy is
derived from fructose
 Fructose is the major energy source for
spermatozoa in the seminal vesicle
 Breakdown (fructolysis) :
 In Liver, kidney , small intestine :
o Enzyme Fructokinase convert fructose to F1P,
using ATP as the phosphate donor.
o F1P is cleaved by aldolase B (also called fructose 1-phosphate aldolase) to two trioses,
dihydroxyacetone phosphate (DHAP) and glyceraldehyde
• Aldolase �ន 3 isozyme : A,B,C
 A : in most tissue
 B : in Liver, kidney , and small intestine (only B that can cleave F1P)
 C: in brain
 All A,B,C can convert F-1,6-biP to DHAP and glyceraldehyde-3-P in glycolysis
o Glyceraldehyde can phosphorylate to Glyceraldehyde-3-P by triose kinase
o DHAP and Glyceraldehyde-3-P  either glycolysis or gluconeogenesis
By: Savath Sovannak
 In most tissue :
o Tissue other than Liver, kidney , small intestine មិន�ន enzyme
fructokinase េទ, but they contain enzyme hexokinase  it can
phosphorylate fructose to F6P
o Hexokinase has high Km for fructose  Fructokinase provides
the primary mechanism for fructose phosphorylation because it
has low Km for fructose

By: Savath Sovannak


By: Savath Sovannak
 To trapped Glucose within the cells  the cell can either
phosphorylation or reduced it to Sorbitol by Aldose reductase
 Aldose reductase :
o Found in many tissues, including the retina, lens, kidneys,
peripheral nerves, ovaries, and seminal vesicles.
o It has high Km for glucose
 Fructose can be produced from glucose via sorbitol without using ATP
 Sorbitol dehydrogenase, can oxidize sorbitol to fructose in cells of
the liver, ovaries, and seminal vesicles

By: Savath Sovannak

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