CELL CYCLE AND CELL DIVISION

1. Which one of the following never occurs during mitotic cell division
A. Coiling and condensation of the chromatids
B. Spindle fibres attach to kinetochores of chromosomes
C. Movement of centrioles towards opposite poles
D. Pairing of homologous chromosomes
2. The appearance of recombination nodules on homologous chromosomes during
meiosis characterizes
A. Terminalization B. Synaptonemal complex
B. Bivalent D. Sites at which crossing over occurs
3. Select the incorrect statement with reference to mitosis:
A. Splitting of centromere occurs at anaphase
B. All the chromosomes lie at the equator at metaphase
C. Spindle fibres attach to centromere of chromosomes
D. Chromosomes decondense at telophase
4. Regarding Meiosis, which of the statements is incorrect
A. Four haploid cells are formed at the end of Meiosis-II
B. There are two stages in Meiosis, Meiosis-I and II
C. DNA replication occurs in S phase of Meiosis-II
D. Pairing of homologous chromosomes and recombination occurs in Meiosis-I
5. Which of the following stages of meiosis involves division of centromere
A. Metaphase II B. Anaphase II C. Telophase II D. Metaphase I
6. Match List - 1 with List - 2
List - 1 List - 2
A. S phase (i) Proteins are synthesized
B. G2 phase (ii) Inactive phase
C. Quiescent stage (iii) Interval between mitosis and initiation of
DNA replication
D. G1 phase (iv) DNA replication

Choose the correct answer from the options given below.

a. A-iv B-ii C-iii D-i
b. A-iv B-i C-ii D-iii
c. A-ii B-iv C-iii D-i
d. A-iii B-ii C-i D-iv
7. The fruit fly has 8 chromosomes (2n) in each cell. During interphase of Mitosis if
the number of chromosomes at G1 phase is 8, what would be the number of
chromosomes after S phase
A. 16 B. 4 C. 32 D. 8
8. Which stage of meiotic prophase shows terminalisation of chiasmata as its
distinctive feature
A. Zygotene B. Diakinesis C. Pachytene D. Leptotene
9. The centriole undergoes duplication during:
A. Prophase B. Metaphase C. G2 phase D. S-phase
10. Match the following with respect to meiosis:
Column-I Column-II
1. Zygotene (i) Terminalization
2. Pachytene (ii) Chiasmata
 CELL CYCLE AND CELL DIVISION

3. Diplotene (iii) Crossing over

4. Diakinesis (iv) Synapsis
Select the correct option from the following:
(1) (2) (3) (4)
a. (iv) (iii) (ii) (i)
b. (i) (ii) (iv) (iii)
c. (ii) (iv) (iii) (i)
d. (iii) (iv) (i) (ii)
11. Identify the correct statement with regard to G1 phase (Gap 1) of interphase
A. Reorganisation of all cell components takes place
B. Cell is metabolically active, grows but does not replicate its DNA
C. Nuclear division takes place
D. DNA synthesis or replication takes place
12. Dissolution of the synaptonemal complex occurs during:
A. Zygotene B. Diplotene C. Leptotene D. Pachytene
13. Some dividing cells exit the cell cycle and enter vegetative inactive stage. This is
celled quiescent stage (G0). This process occurs at the end of:
A. G1 phase B. S phase C. G2 phase D. M phase
14. In a mitotic cycle, the correct sequence of phases is
A. G1, S, G2, M B. M, G1, G2, S C. G1,G2,S, M D. S, G1,G2 , M
15. Attachment of spindle fibers to kinetochores of chromosomes becomes evident
In:
A. Telophase B. Prophase C. Metaphase D. Anaphase*
16. Match the following events that occur in their respective phases of cell cycle
and select the correct option:
1. G1 phase (i) Cell grows and organelle duplication
2. S phase (ii) DNA replication and chromosome duplication
3. G2 phase (iii) Cytoplasmic growth
4. Metaphase in (iv) Alignment of chromosomes
M-phase

(1) (2) (3) (4)

a. (iii) (iv) (i) (ii)
b. (iv) (i) (ii) (iii)
c. (i) (ii) (iii) (iv)
d. (ii) (iii) (iv) (i)
17. During Meiosis I, in which stage synapsis takes place
A. Zygotene B. Diplotene C. Leptotene D. Pachytene
18. The correct sequence of phases of cell cycle is
A. ???????????????????????
19. Cell in G0 phase
A. Exit the cell cycle B. Enter the cell cycle
C. Suspend the cell cycle D. Terminate the cell cycle
20. The stage during which separation of the paired homologous chromosomes
begins is
A. Pachytene B. Diplotene C. Diakinesis D. Zygotene
 CELL CYCLE AND CELL DIVISION

21. Which of the following options gives the correct sequence of events during
mitosis
A. ???????????????????????
22. Anaphase promoting complex (APC) is a protein degradation machinery
necessary for proper mitosis of animal cells, if APC is defective in a human cell, which
of the following is expected to occur
A. Chromosomes will not condense B. Chromosomes will be fragmented
C.Chromosomes will not segregate D. Recombination of chromosome arms will occur
23. DNA replication in bacteria occurs:
A. During S-phase B. Within nucleolus
C. Prior to fission D. Just before transcription
24. Which of the following statement is correct with respect to cell cycle
A. DNA content of cell remains constant during entire cell cycle
B. A cell in G1 phase has double the amount of DNA than a cell in G2 phase
C. Each chromosome has two chromatids in G1 phase
D. Nerve cells in adult human are in G0 state
25. At what phase of meiosis homologous chromosomes are separated
A. Anaphase II B. Prophase I C. Prophase II D. Anaphase I
26. Match the stages of meiosis in Column- I to their characteristic features in
Column -II and select the correct option using the codes given below:
Column I Column II
A. Pachytene i. Pairing of homologous chromosomes
B. Metaphase-I ii. Terminalisation of chiasmata
C. Diakinesis iii. Crossing over takes place
D. Zygotene iv. Chromosomes align at equatorial plate
Codes:
a. A-ii B-iv C-iii D-i
b. A-iv B-iii C-ii D-i
c. A-iii B-iv C-ii D-i
d. A-i B-iv C-ii D-iii
27. When cell has stalled DNA replication fork, which checkpoint should be
predominantly activated
A. M B. Both G2/M and M C. G1/S D. G2/M
28. During cell growth, DNA synthesis takes place in:
A. G2 phase B. M phase C. S phase D. G1 phase
29. Which of the following is not a characteristic feature during mitosis in somatic
cells
A. Spindle fibres B. Disappearance of nucleolus
C . CHromosome movement D. Synapsis
30. In meiosis, crossing over is initiated at:
A. Pachytene B. Leptotene C. Zygotene D. Diplotene
31. Select the correct option:
Column I Column II
A. Synapsis aligns the homologous i. Anaphase-II
Chromosomes
B. Synthesis of RNA and protein ii. Zygotene
C. Action of enzyme recombinase iii. G2 -phase
 CELL CYCLE AND CELL DIVISION

D. Centromeres do not separate iv. Anaphase-I

But chromatids move towards
Opposite poles
v. Pachytene
a. A-i B-ii C-iii D-iv
b. A-ii B-iii C-iv D-v
c. A-ii B-i C-iii D-iv
32. A somatic cell that has just completed the S phase of its cell cycle, as compared
to gamete of the same species, has:
A. Twice the number of chromosomes and four times the amount of DNA
B. Four times the number of chromosomes and twice the amount of DNA
C. Twice the number of chromosomes and twice the amount of DNA
D. Same number of chromosomes but twice the amount of DNA
33. Arrange the following events of meiosis in correct sequence:
A. Crossing over B. Synapsis
B. Terminalisation of chiasmata D. Disappearance of nucleolus
a. (B), (A), (C), (D), b. (A), (B), (C), (D), c. (B), (C), (D), (A) d. (B), (A), (D), (C)
34. The enzyme recombinase is required at which stage of meiosis
A. Diakinesis B. Pachytene C. Zygotene D. Diplotene
35. During which phase (s) of cell cycle, amount of DNA in a cell remains at 4C level if
the initial amount is denoted as 2C
A. G2 and M B. G0 and G1 C. G1 and S D. Only G2
36. In ‘S’ phase of the cell cycle:
A. Amount of DNA is reduced to half in each cell
B. Amount of DNA doubles in each cell
C. Amount of DNA remains same in each cell
D. Chromosome number is increased
37. The complex formed by a pair of synapsed homologous chromosomes is called
A. Axoneme B. Equatorial plate C. Kinetochores D. Bivalent
38. Which of the following activity takes place in G2 phase
A. Synthesis of proteins B. Formation of centriole
C.Duplication of chromosome D. Both (a) and (b)
39. In human, cell division lasts for about__________
A. 12 hour B. 90 minutes C. 1 hour D. 36 hour
40. In human, one complete cell cycle has different phases that last for different time.
The interphase lasts for more than
A. 80% B. 5% C. 90% D. 95%
41. G0 phase of a cell indicates
A. Death of cell B. Check point before entering next phase
C. Exit of cell from cell cycle D. Suspended cell cycle/temporary pause
42. If a cell consist of DNA higher than the normal level in the functional cell, the cell
A. Has completed division B. Is preparing to divide
C. Has ceased to function D. Has reached to end of the phase of life
43. Yeast cell can progress through the cell cycle in about
A. 30 min B. 60 min C. 90 min D. 120 min
44. the phase between two successive M phases
A. Interphase B. Telophase C. Anaphase D. S-phase
 CELL CYCLE AND CELL DIVISION

45. Most of the organelle duplication takes place in

A. M-phase B. Interphase C. Interkinesis D. Centriole
46. Interphase includes
A. G1 phase B. S phase C. G2 phase D. All of these
47. Duplication of centriole takes place in the
A. Nucleus B. Mitochondria C. Cytoplasm D. Both (a) and (c)
48. During cell division
A. DNA replication does not occur
B. Cell growth does not occur
C. Increase in cytoplasm of daughter cell does not occur
D. Division of cell organelles does not occur
49. DNA replication occur
A. Twice in each cell cycle
B. Only once in each cell cycle
C. Once in mitotic cell cycle, once in meiotic-l and once in meiotic-ll
D. None of these
50. The sequence of events in which a cell duplicates its genome, synthesises the
other constituents of the cell and eventually divides into two daughter cells is called
A. Cell division B. Cell cycle C. Karyokinesis D. Cytokinesis
51. A typical eukaryotic cell cycle is illustrated by
A. Yeast B. Bacteria C. Human cell in culture D. Both (a) and (c)
52. While studying mitosis, if the number of chromosome in cell of root tip of a plant
is 14, then how many chromosome will the cell have after S-phase
A. 14 B. 7 C. 28 D. None of these
53. Mature nerve cells cannot undergo cell division. These cells are probably
considered in
A. G2 - phase B. S - phase C. Mitosis D. G0 - phase
54. Decision of G0 - phase occurs
A. Towards the end of G1 - phase B. Before the middle of G1 - phase
C. At the end of telophase D. Towards the end of cytokinesis
55. Which stage of cell cycle prepares the cell for division
A. Mitosis B. Interphase C. Interkinesis D. None of these
56. Interphase is also known as________stage and it takes about _______time of cell
cycle:
A. Dividing, 95% B. Replicating, 30% C. Resting, 95% D. Resting, 80%
57. Metabolically active but non-proliferative stage is
A. G1 B. G0 C. G2 D. S phase
58. Identify the correct sequence of cell cycle
A. S, G1, G2, M B.S, M, G1, G2 C. G1, S, G2, M D. G2, S, M, G1
59. If the initial amount of DNA is denoted as 2C then the amount of DNA after
S-phase will be :
A. 4C B. 6C C. C D. 2C
60. In which of the following stage, Golgi apparatus, ER and nucleolus reform
A. Anaphase B. Prophase C. Telophase D. Interphase
61. Arrange the following stages in correct sequence
A. G1 -- S -- G2 -- M where M proceeds as Telophase -- Prophase -- Anaphase --
Metaphase