Nephron
and
Urine formation
Lesson objectives
To describe nephron structure and function
To explain the mechanisms of filtration and
urine formation
Lets think!
Why does the analysis for bad habits
require urine test ?
Functions of the
kidneys
filters
blood
makes urine.
Nephrons
Each kidney
consists of
millions of
nephrons.
Nephrons are
the fundamental
units of the
kidney.
Nephron’s functions:
It filters blood to:
Regulate of water balance
Regulate of mineral, salts balance
Nephron structure
Glomerulus
Bowman’s capsule
Convoluted tubules:
proximal and distal
A loop of Henle
Collecting duct
Steps of urine formation:
1) Filtration
2) Reabsorption
3) Secretion
Filtration
Filtration
Ittakes place in glomerulus and
Bowman’s capsule
A closer look to the glomerulus and
Bowman’s capsule
Each glomerulus is formed by network of capillaries that is branch of renal
arteriole.
Renal arteriole through which blood flows into glomerulus is called as afferent
arteriole.
Arteriole through which blood leaves glomerulus is called as efferent arteriole.
Glomerulus has only one cell thick walls with many pores, so some materials
can leave glomerulus and pass into Bowman’s capsule.
Bowman’s capsule is cup-shaped structure that surround glomerulus. It has
very thin walls with only one cell-thick.
Afferent
arteriole
Efferent
arteriole
Filtration process
Blood pass from afferent arteriole into
glomerulus.
Glomerulus has high blood pressure
which forces small materials of
plasma, such as ions, urea, amino
acids, salts, glucose, water etc to pass
into Bowman’s capsule
So blood is filtered through the filtrate
glomerulus, allowing small substances
to pass into Bowman’s capsule, but
large materials such as blood cells and
proteins remain in blood.
The filtrate enters renal tubules is
called.
Reabsorption
Reabsorption
Ittakes place in renal tubules (convoluted
tubules: proximal and distal, loop of Henle,
collecting duct).
Renal tubules:
proximal tubule, loop
of Henle, distal tubule
are covered by
network of capillaries.
Process of reabsorption
As the filtrate flows
through the renal tubule ,
most of water and
nutrients are reabsorbed
into the blood.
Secretion
Secretion
It takes place into
renal tubule.
Substances
including H+,
potassium, uric
acid, ammonium,
toxic substances
enter the tubules
from blood.
The concentrated
fluid that remains is
called urine.
What is Urine?
Urine is a liquid waste that is 95% water.
The remainder consists of:
Urea (majority) and uric acid
Ammonia
Hormones
Dead blood cells
Proteins, salts, and minerals
Various Toxins.
What happens to urine?
Urine flows into collecting
duct and then into ureters
that lead to urinary bladder.
Urinary bladder store urine
temporary.
Urine leaves bladder and
body through urethra.
5
1 2
4
Let’s do the activity on p. 55
Homework
Readp. 54-55
Answer to literacy questions on p 55.
New words